A study on keratan sulphate as a molecular marker to monitor cartilage metabolism in horses
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MATTERS ARISING EVects of methotrexate on cartilage metabolism
We read with interest the report by Neidal et al on the eVects of methotrexate (MTX) on articular cartilage in vitro and in vivo. The relevance of these findings to patients with rheumatoid arthritis (RA) and other diseases who are receiving MTX is of considerable interest. In a previous study we reported that treatment of RA patients with MTX resulted in reduced numbers of leucocytes and reduc...
متن کاملMATTERS ARISING EVects of methotrexate on cartilage metabolism
We read with interest the report by Neidal et al on the eVects of methotrexate (MTX) on articular cartilage in vitro and in vivo. The relevance of these findings to patients with rheumatoid arthritis (RA) and other diseases who are receiving MTX is of considerable interest. In a previous study we reported that treatment of RA patients with MTX resulted in reduced numbers of leucocytes and reduc...
متن کاملMATTERS ARISING EVects of methotrexate on cartilage metabolism
We read with interest the report by Neidal et al on the eVects of methotrexate (MTX) on articular cartilage in vitro and in vivo. The relevance of these findings to patients with rheumatoid arthritis (RA) and other diseases who are receiving MTX is of considerable interest. In a previous study we reported that treatment of RA patients with MTX resulted in reduced numbers of leucocytes and reduc...
متن کاملKeratan sulphate in rheumatoid arthritis, osteoarthritis, and inflammatory diseases.
Serum concentrations of antigenic keratan sulphate determined by an enzyme linked immunosorbent assay (ELISA) with a monoclonal antibody were studied in patients with rheumatoid arthritis (RA), osteoarthritis, ankylosing spondylitis, other inflammatory diseases, and a large control group of women without arthritis. Mean keratan sulphate concentrations were low in 117 women with RA compared with...
متن کاملImmunolocalization of keratan sulphate in the human embryonic cornea and other human foetal organs.
An antibody raised against keratan sulphate was used to localize keratan sulphate in the human embryonic cornea and other human foetal organs. It was found that keratan sulphate was present in the corneal endothelium, as well as in the corneal stroma. In contrast, no keratan sulphate could be demonstrated in the corneal epithelium or in any posterior parts of the human foetal eye. Human corneal...
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